Imaging
Consensus recommendations for localized and whole-body MRI acquisition, interpretation, and imaging response evaluation in NF clinical trials.
Leadership
About This Group
The goal of the Imaging working group is to generate standardized consensus recommendations for both localized and whole body magnetic resonance (MR) image acquisition and interpretation for the detection, characterization and imaging response evaluation of benign and malignant neoplasms, using a multi-parametric and volumetric analysis.
Current group leaders: Eva Dombi, MD and Shivani Ahlawat, MD Past group leader: Jaishri Blakeley, MD
- Evaluate test-retest variability and interobserver performance of WB-MRI in NF.
- Investigate the diagnostic accuracy of quantitative functional and metabolic localized and functional imaging techniques for tumor characterization and assessment of treatment response.
- Investigate the added value of contrast-enhanced imaging to both localized and WB-MRI protocols for tumor characterization and assessment of treatment response.
Additional Information
No additional sections yet.
Working Group Snapshot & Focus Updates
Current research areas: (1) Evaluate test-retest variability and interobserver performance of WB-MRI in NF. (2) Investigate the diagnostic accuracy of quantitative functional and metabolic localized imaging for tumor characterization and assessment of treatment response. (3) Investigate the added value of contrast-enhanced imaging to both localized and WB-MRI protocols.
Publications & References
Imaging Evaluation of Plexiform Neurofibromas in Neurofibromatosis Type 1
Shivani Ahlawat, K. Ina Ly, Laura M. Fayad, Michael J. Fisher, Andrés J. Lessing, Dale J. Berg, Johannes M. Salamon, Victor-Felix Mautner, Dusica Babovic-Vuksanovic, Eva Dombi, GordonHarris, Scott R. Plotkin, Jaishri Blakeley. Imaging Evaluation of Plexiform Neurofibromas in Neurofibromatosis Type 1. Neurology 2021. Aug 2021; 97 (7 Supplement 1) S111-S119; DOI:10.1212/WNL.0000000000012437.
Current whole-body MRI applications in the neurofibromatoses
Ahlawat S, Fayad LM, Khan MS, et al. Current whole-body MRI applications in the neurofibromatoses: NF1, NF2, and schwannomatosis. Neurology 2016 Aug 16;87(7 Suppl 1): S31-9
Recommendations for imaging tumor response in neurofibromatosis clinical trials
Dombi E, Ardern-Holmes SL, Babovic-Vuksanovic D, et al. Recommendations for imaging tumor response in neurofibromatosis clinical trials. Neurology 2013 Nov 19;81(21 Suppl 1):S33-S40.
Documents & Resources
Join or Contact This Group
Membership is open to all interested parties. Meetings are primarily held by teleconference.
Express Interest